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April 1, 1992AJP Heart and Circulatory Physiology

Porous medium finite element model of the beating left ventricle

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Population

Axisymmetric porous medium finite element model representing myocardial tissue as a spongy anisotropic…

Comparison

Simulation of cardiac cycle mechanics including… vs Simulations with suppression of intracoronary…

Design

Preclinical

Authors

JHJacques M. HuygheUniversity of LimerickTATheo ArtsElectrophysiologyDCD.H. van CampenRoyal Netherlands Academy of Arts and Sciences

Discussion

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Implication

Intracoronary redistribution may limit intramyocardial pressure in animals; leaves open its role in human ventricular mechanics.

Key Points

  • Develop an axisymmetric finite element model representing the left ventricle as a porous, anisotropic, viscoelastic material to assess myocardial mechanics and intramyocardial fluid movement.
  • Formulated an axisymmetric porous-medium finite element model incorporating ventricular torsion, transmural fiber angle variation, and intracoronary blood redistribution.
  • Simulated myocardial strain and pressure distributions during normal cardiac cycles, under conditions with suppressed blood redistribution, and during unloaded contraction (0 kPa).
  • Peak equatorial intramyocardial pressure differed by <5% from peak intraventricular pressure during normal cycles, but exceeded it by >30% when intracoronary blood redistribution was suppressed.
  • Maximal shortening direction varied by <30 degrees across the wall despite a >100 degrees shift in fiber direction, with end-systolic principal strains reaching 0.45, -0.01, and -0.24 at two-thirds wall depth from the epicardium.
  • Contraction in an unloaded left ventricle generated systolic intramyocardial pressures of similar magnitude to the normal cycle, with transmural stress remaining highly sensitive to fiber angle distribution.

Structured PICO

P
Population
Axisymmetric porous medium finite element model representing myocardial tissue as a spongy anisotropic viscoelastic material
I
Intervention
Simulation of cardiac cycle mechanics including torsion, transmural fiber angle variation, and intracoronary blood redistribution
C
Comparator
Simulations with suppression of intracoronary blood redistribution; unloaded left ventricle (left ventricular pressure = 0 kPa)
O
Outcome
End-systolic principal strains, intramyocardial pressure, and transmural systolic fiber stress distribution

A porous medium finite element model demonstrates that intracoronary blood redistribution significantly affects intramyocardial pressure during the cardiac cycle.

Cite This Study

Huyghe et al. (1992) studied this question.

synapsesocial.com/papers/6a154b5779ff98d0de4e6582https://doi.org/10.1152/ajpheart.1992.262.4.h1256
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Finite Element Analysis of End-Diastolic and End-Systolic Fiber Stress in the Canine Left Ventricle1995
  2. 2Mechanical model of the left ventricle of the heart approximated by axisymmetric geometry2017 · 7 citations
  3. 3A finite element model of the human left ventricular systole2006 · 41 citations
  4. 4A computer study of the left ventricular performance based on fiber structure, sarcomere dynamics, and transmural electrical propagation velocity.1984 · 140 citations
  5. 5Mathematical model of geometry and fibrous structure of the heart1991 · 657 citations