Key result
Computational modeling of five normal human left ventricles predicted end-diastolic and end-systolic myofiber stress fields of 2.21 ± 0.58 kPa and 16.54 ± 4.73 kPa, respectively.
Personalized computational models of normal human left ventricles established reference end-diastolic and end-systolic myofiber stress fields, providing targets for in silico design of heart failure treatments.
Reference myofiber stresses from normal LV models may inform in silico HF therapy design; leaves open validation in diseased hearts before clinical use.
Ventricular wall stress is believed to be responsible for many physical mechanisms taking place in the human heart, including ventricular remodeling, which is frequently associated with heart failure. Therefore, normalization of ventricular wall stress is the cornerstone of many existing and new treatments for heart failure. In this paper, we sought to construct reference maps of normal ventricular wall stress in humans that could be used as a target for in silico optimization studies of existing and potential new treatments for heart failure. To do so, we constructed personalized computational models of the left ventricles of five normal human subjects using magnetic resonance images and the finite-element method. These models were calibrated using left ventricular volume data extracted from magnetic resonance imaging (MRI) and validated through comparison with strain measurements from tagged MRI (950 ± 170 strain comparisons/subject). The calibrated passive material parameter values were C0 = 0.115 ± 0.008 kPa and B0 = 14.4 ± 3.18; the active material parameter value was Tmax = 143 ± 11.1 kPa. These values could serve as a reference for future construction of normal human left ventricular computational models. The differences between the predicted and the measured circumferential and longitudinal strains in each subject were 3.4 ± 6.3 and 0.5 ± 5.9%, respectively. The predicted end-diastolic and end-systolic myofiber stress fields for the five subjects were 2.21 ± 0.58 and 16.54 ± 4.73 kPa, respectively. Thus these stresses could serve as targets for in silico design of heart failure treatments.
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Genet et al. (2014) studied Healthy volunteers (n=5). Computational modeling of left ventricular myofiber stress was evaluated on End-diastolic and end-systolic myofiber stress. Computational modeling of five normal human left ventricles predicted end-diastolic and end-systolic myofiber stress fields of 2.21 ± 0.58 kPa and 16.54 ± 4.73 kPa, respectively.
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