Verified the existence of three complexes of group A arboviruses based on antigenic relationships.
Supports arbovirus antigenic classification in animal models; extends prior groupings but leaves human translation open.
Antigenic relationships of 20 group A arboviruses were assessed by the plaque reduction neutralization test, using highly specific hyperimmune mouse ascitic fluids and antisera. The existence of three complexes of group A viruses was verified. With rare exceptions, heterologous neutralization reactions were observed only among viruses in the same complex; however there were at least one or two immune reagents in each complex which were broadly cross-reactive within that complex.
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Nick Karabatsos (1975) studied this question.
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