Key result
Voltage-sensitive dye mapping in isolated mouse atria revealed shorter action potential durations in the left versus right atrium, validating a new approach for monitoring atrial electrophysiology.
Population
in vitro mouse heart preparation consisting of both atria in isolation
Design
Preclinical
Authors
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Extends myocyte data to intact mouse atria; supports model utility but leaves human translation open.
Voltage-sensitive dye mapping is a valid approach for monitoring electrophysiological properties in isolated mouse atria, demonstrating that their physiological and pharmacological properties closely resemble those of larger mammals.
Nygren et al. (2004) studied this question. Voltage-sensitive dye mapping (di-4-ANEPPS) was evaluated on Action potential durations (APDs) and activation patterns. Voltage-sensitive dye mapping in isolated mouse atria revealed shorter action potential durations in the left versus right atrium, validating a new approach for monitoring atrial electrophysiology.
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