Key result
Mouse myocardium exhibits action potential cycle length dependence and electrical restitution properties similar to larger mammals, with APD30 reaching plateau faster than APD90 (P<0.01).
Population
21 isolated, Langendorff-perfused, and atrioventricular node-ablated mouse hearts, and isolated ventricular…
Design
Preclinical
Authors
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Supports mouse models for arrhythmia electrophysiology research; leaves open translation to human myocardium.
p-value: p=<0.01
Mouse myocardium exhibits action potential cycle length dependence and electrical restitution properties similar to larger mammals, supporting its utility in arrhythmia research.
Knollmann et al. (2006) studied this question. Steady-state pacing and varied coupling intervals was evaluated on Action potential duration (APD) restitution kinetics (p=<0.01). Mouse myocardium exhibits action potential cycle length dependence and electrical restitution properties similar to larger mammals, with APD30 reaching plateau faster than APD90 (P<0.01).
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