Key result
Advancing age in patients with paroxysmal atrial fibrillation was associated with a significantly greater mean number of abnormal atrial electrograms (>60 years: 2.58 vs <60 years: 1.43; p<0.004).
Why the study?
Does advancing age increase the abnormality of atrial endocardial electrograms in patients with paroxysmal atrial fibrillation?
Population
111 patients with paroxysmal atrial fibrillation (PAF)
Comparison
Advancing age (age > 60 years) vs Younger age (age < 60 years)
Design
Cross-sectional
Authors
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May support age-stratified substrate assessment in paroxysmal AF; hypothesis-generating and requires prospective validation before guiding ablation.
Observational (n=111)
Does advancing age increase the abnormality of atrial endocardial electrograms in patients with paroxysmal atrial fibrillation?
Absolute Event Rate: 2.58% vs 1.43%
p-value: p=< 0.004
Advancing age is associated with increased electrophysiologic abnormalities in the right atrium of patients with paroxysmal atrial fibrillation, reflecting progressive age-related atrial remodeling.
Camm et al. (2003) conducted an observational in paroxysmal atrial fibrillation (n=111). Age > 60 years vs. Age < 60 years was evaluated on Number of abnormal atrial electrograms (p=< 0.004). Advancing age in patients with paroxysmal atrial fibrillation was associated with a significantly greater mean number of abnormal atrial electrograms (>60 years: 2.58 vs <60 years: 1.43; p<0.004).
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