Key result
Advancing age was strongly associated with a progressive decline in right (r=-0.77, P<0.0001) and left (r=-0.79, P<0.001) atrial wavefront propagation velocities and increased septal refractoriness.
Why the study?
Is advancing age associated with changes in biatrial electrophysiology in patients with structurally normal hearts and no history of atrial fibrillation?
Observational (n=23)
Is advancing age associated with changes in biatrial electrophysiology in patients with structurally normal hearts and no history of atrial fibrillation?
Effect estimate: r=-0.77 (right), r=-0.79 (left)
p-value: p=<0.0001 (right), <0.001 (left)
Advancing age is associated with a progressive decline in atrial wavefront propagation velocity and an increase in septal refractoriness, providing a potential electrophysiological substrate for the age-related increase in atrial fibrillation prevalence.
No takes yet. Share an insight, caveat, or question.
May underlie rising AF risk with age; hypothesis-generating and requires prospective validation before clinical relevance.
Kojodjojo et al. (2005) conducted an observational in Left-sided accessory pathways with structurally normal hearts and no history of atrial fibrillation (n=23). Advancing age (Electroanatomic mapping) was evaluated on Correlation of right and left atrial wavefront propagation velocities (WPV) with age (r=-0.77 (right), r=-0.79 (left), p=<0.0001 (right), <0.001 (left)). Advancing age was strongly associated with a progressive decline in right (r=-0.77, P<0.0001) and left (r=-0.79, P<0.001) atrial wavefront propagation velocities and increased septal refractoriness.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: