Key result
Diabetes linked to ~336% higher risk of AF recurrence after cryoballoon PVI.
Why the study?
Diabetes mellitus plays a crucial role in atrial fibrillation regulation, but outcomes of single-shot device pulmonary vein isolation in patients with AF and DM needed evaluation.
Does diabetes mellitus increase the recurrence of atrial fibrillation in patients undergoing cryoballoon-guided pulmonary vein isolation?
Cohort (n=531)
Does diabetes mellitus increase the recurrence of atrial fibrillation in patients undergoing cryoballoon-guided pulmonary vein isolation?
Effect estimate: HR 4.363 (95% CI 1.456-13.074)
p-value: p=0.009
Diabetes mellitus significantly increases the risk of atrial fibrillation recurrence after cryoballoon ablation in patients with paroxysmal AF, but not persistent AF.
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DM may warrant closer post-ablation surveillance in paroxysmal AF; hypothesis-generating for glycemic intervention trials.
Guckel et al. (2021) conducted a cohort in Atrial fibrillation (n=531). Diabetes Mellitus vs. Patients without Diabetes Mellitus was evaluated on First documented recurrence of atrial tachyarrhythmia (HR 4.363, 95% CI 1.456-13.074, p=0.009). Diabetes mellitus independently predicted atrial fibrillation recurrence after cryoballoon-guided pulmonary vein isolation in patients with paroxysmal AF (HR 4.363; 95% CI 1.456-13.074; P=0.009).
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