Key result
Elevated systolic blood pressure in young adults is primarily associated with increased cardiac output in normal-weight individuals, but with increased peripheral vascular resistance in overweight individuals.
Cross-Sectional (n=2,502)
Yes
The haemodynamic mechanisms driving elevated blood pressure in young adults differ by adiposity and sex, suggesting that personalized approaches may be needed for hypertension management in this population.
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Supports adiposity-specific BP mechanisms in young adults; hypothesis-generating for targeted trials before practice change.
Middlemiss et al. (2015) conducted a cross-sectional in Elevated systolic blood pressure (n=2,502). Adiposity (BMI) vs. Normal weight vs Overweight was evaluated on Hemodynamic mechanisms (cardiac output and peripheral vascular resistance) associated with elevated SBP. Elevated systolic blood pressure in young adults is primarily associated with increased cardiac output in normal-weight individuals, but with increased peripheral vascular resistance in overweight individuals.
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