Key result
Propranolol blocks cardiac and brain voltage-gated sodium channels in a tonic and phasic manner, acting similarly to class 1 antiarrhythmic drugs.
Population
Heterologously expressed recombinant human cardiac and brain sodium channels
Design
Editorial
Authors
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Propranolol exerts direct blocking effects on cardiac Nav1.5 sodium channels similar to class 1 antiarrhythmics, providing a molecular mechanism for its antiarrhythmic properties beyond beta-adrenergic blockade.
Propranolol exerts direct blocking effects on cardiac Nav1.5 sodium channels similar to class 1 antiarrhythmics, providing a molecular mechanism for its antiarrhythmic properties beyond beta-adrenergic blockade.
Mohamed Chahine (2011) reported an editorial. Propranolol was evaluated. Propranolol blocks cardiac and brain voltage-gated sodium channels in a tonic and phasic manner, acting similarly to class 1 antiarrhythmic drugs.
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