Propranolol blocks cardiac and brain voltage-gated sodium channels in a tonic and phasic manner, acting similarly to class 1 antiarrhythmic drugs.
Propranolol exerts direct blocking effects on cardiac Nav1.5 sodium channels similar to class 1 antiarrhythmics, providing a molecular mechanism for its antiarrhythmic properties beyond beta-adrenergic blockade.
GENERAL COMMENTARY article Front. Pharmacol., 19 January 2011Sec. Pharmacology of Ion Channels and Channelopathies volume 2 - 2011 | https://doi.org/10.3389/fphar.2011.00001
Mohamed Chahine (Sat,) reported a editorial. Propranolol was evaluated. Propranolol blocks cardiac and brain voltage-gated sodium channels in a tonic and phasic manner, acting similarly to class 1 antiarrhythmic drugs.
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