July 15, 2010Journal of Hypertension
Microalbuminuria as a risk factor: the influence of renin–angiotensin system blockade
Key result
Microalbuminuria is a significant cardiovascular risk factor in both diabetic and nondiabetic patients, and renin-angiotensin system blockade has demonstrated success in its treatment.
Why the study?
Does renin-angiotensin system blockade reduce microalbuminuria and cardiovascular risk in patients with or without diabetes?
Population
General population and diabetic patients with or at risk of microalbuminuria
Design
Review
Authors
Discussion
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Implication
Supports microalbuminuria screening and RAS blockade in diabetic and nondiabetic patients; leaves open large-scale trial confirmation of CV benefit.
Structured PICO
Does renin-angiotensin system blockade reduce microalbuminuria and cardiovascular risk in patients with or without diabetes?
P
Population
General population and diabetic patients with or at risk of microalbuminuria
I
Intervention
Renin-angiotensin system blockade (angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers)
O
Outcome
Reduction of microalbuminuria and cardiovascular risk
Highlights the importance of screening for and treating microalbuminuria with renin-angiotensin system blockade to reduce cardiovascular risk.
Cite This Study
Menne et al. (2010) conducted a review in Microalbuminuria and cardiovascular risk. Renin-angiotensin system blockade (ACE inhibitors and ARBs) was evaluated. Microalbuminuria is a significant cardiovascular risk factor in both diabetic and nondiabetic patients, and renin-angiotensin system blockade has demonstrated success in its treatment.