Key result
Baseline microalbuminuria independently predicted an increased risk of developing chronic renal insufficiency in hypertensive patients without diabetes (adjusted RR 12.75; 95% CI 3.62-44.92; P<0.0001).
Why the study?
Does microalbuminuria predict the development of chronic renal insufficiency and cardiovascular events in patients without diabetes and with primary hypertension?
Population
917 patients without diabetes and with primary hypertension enrolled in the Microalbuminuria: A Genoa…
Comparison
Baseline microalbuminuria vs Normoalbuminuria
Design
Cohort
Follow-up
11.8 years
Authors
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Suggests closer renal monitoring for non-diabetic hypertensives with microalbuminuria; hypothesis-generating and requires prospective confirmation before changing practice.
Cohort (n=917)
Does microalbuminuria predict the development of chronic renal insufficiency and cardiovascular events in patients without diabetes and with primary hypertension?
Effect estimate: RR 12.75 (95% CI 3.62-44.92)
p-value: p=<0.0001
Microalbuminuria is an independent predictor of long-term renal and cardiovascular complications in non-diabetic patients with primary hypertension.
Viazzi et al. (2010) conducted a cohort in Hypertension without diabetes (n=917). Microalbuminuria vs. No microalbuminuria was evaluated on Chronic renal insufficiency (CRI) (RR 12.75, 95% CI 3.62-44.92, p=<0.0001). Baseline microalbuminuria independently predicted an increased risk of developing chronic renal insufficiency in hypertensive patients without diabetes (adjusted RR 12.75; 95% CI 3.62-44.92; P<0.0001).
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