Key result
Preoperative use of renin-angiotensin system inhibitors did not increase the risk of postoperative acute kidney injury compared to no use in patients undergoing OPCAB (19.9% vs 20.9%, P=0.815).
Why the study?
Does preoperative use of renin-angiotensin system inhibitors increase the risk of acute kidney injury in patients undergoing off-pump coronary artery bypass grafting?
Population
472 patients who underwent off-pump coronary artery bypass grafting (OPCAB)
Comparison
Renin-angiotensin system inhibitors for at least… vs No preoperative treatment with RAS inhibitors
Design
Cohort
Follow-up
postoperative
Authors
Loading...
May support continuing preoperative RAS inhibitors in OPCAB without AKI concern; hypothesis-generating and requires randomized confirmation.
Cohort (n=472)
Does preoperative use of renin-angiotensin system inhibitors increase the risk of acute kidney injury in patients undergoing off-pump coronary artery bypass grafting?
Absolute Event Rate: 19.9% vs 20.9%
p-value: p=0.815
Chronic preoperative use of renin-angiotensin system inhibitors does not increase the risk of postoperative acute kidney injury in patients undergoing off-pump coronary artery bypass grafting.
Yoo et al. (2010) conducted a cohort in Off-pump coronary artery bypass grafting (OPCAB) (n=472). Renin-angiotensin system (RAS) inhibitors vs. No RAS inhibitors was evaluated on Incidence of postoperative acute kidney injury (AKI) (p=0.815). Preoperative use of renin-angiotensin system inhibitors did not increase the risk of postoperative acute kidney injury compared to no use in patients undergoing OPCAB (19.9% vs 20.9%, P=0.815).