Key result
Off-pump coronary artery bypass grafting was associated with a significant but transient increase in serum creatinine on postoperative day 1 (P<0.001) that normalized by day 4, with no cases of Stage 2 or higher acute kidney injury.
Why the study?
While off-pump coronary artery bypass grafting aims to curtail perioperative complications, its impact on postoperative acute kidney injury remains debated.
Does off-pump coronary artery bypass grafting (OPCABG) affect postoperative serum creatinine levels and acute kidney injury incidence in patients with coronary artery disease?
Comparison
Preoperative creatinine levels vs postoperative creatinine levels
Design
Retrospective cohort study
Follow-up
Up to 7 days postoperatively
Authors
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Supports acceptable short-term renal safety of OPCABG; leaves open confirmation in randomized trials.
Cohort (n=72)
No
Does off-pump coronary artery bypass grafting (OPCABG) affect postoperative serum creatinine levels and acute kidney injury incidence in patients with coronary artery disease?
Effect estimate: Z value: -4.151
p-value: p=<0.001
OPCABG is associated with a transient, reversible increase in postoperative creatinine without causing severe acute kidney injury, suggesting an acceptable short-term renal safety profile.
Darçın et al. (2023) conducted a cohort in Coronary artery disease (n=72). Off-pump coronary artery bypass grafting (OPCABG) vs. Preoperative baseline was evaluated on Change in serum creatinine levels on postoperative Day 1 compared to baseline (Z value: -4.151, p=<0.001). Off-pump coronary artery bypass grafting was associated with a significant but transient increase in serum creatinine on postoperative day 1 (P<0.001) that normalized by day 4, with no cases of Stage 2 or higher acute kidney injury.
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