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November 1, 2000Anesthesia & Analgesia

Multivariate analysis did not identify OPCAB surgery as an independent predictor of perioperative change in creatinine clearance.

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Why the study?

Does off-pump coronary bypass reduce perioperative change in creatinine clearance in primary elective coronary bypass patients compared to on-pump CABG?

Population

690 primary elective coronary bypass patients

Comparison

Off-pump coronary bypass (OPCAB) vs Coronary bypass surgery with cardiopulmonary…

Design

Cohort

Follow-up

perioperative

Authors

MGMaribel G. GamosoYLYi‐Ju LiKLKevin Landolfo

Discussion

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Overview

OPCAB was not associated with reduced perioperative renal dysfunction; should not yet change practice and leaves open RCT confirmation.

Structured PICO

Does off-pump coronary bypass reduce perioperative change in creatinine clearance in primary elective coronary bypass patients compared to on-pump CABG?

P
Population
690 primary elective coronary bypass patients
I
Intervention
Off-pump coronary bypass (OPCAB)
C
Comparator
Coronary bypass surgery with cardiopulmonary bypass (CABG)
O
Outcome
Perioperative change in creatinine clearance (DCrCl) calculated by using preoperative and peak postoperative serum creatinine valuessurrogate

Off-pump coronary bypass surgery does not significantly reduce perioperative renal dysfunction compared to on-pump CABG, suggesting renal risk reduction alone is not an indication for OPCAB.

Limitations

  • retrospective analysis

Cite This Study

Gamoso et al. (2000) studied this question.

synapsesocial.com/papers/6a1d44005a0c5c56ea04d19fhttps://doi.org/10.1213/00000539-200011000-00007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Does Off-Pump Coronary Artery Bypass Reduce the Incidence of Clinically Evident Renal Dysfunction After Multivessel Myocardial Revascularization?2004 · 61 citations
  2. 2Does Off-Pump Coronary Artery Bypass Grafting Really Preserve Renal Function?2002 · 34 citations
  3. 3Early Evaluation of Renal Function in High-Risk Patients after Off-Pump Coronary Artery Bypass Grafting2016
  4. 4ANALYSIS OF RENAL FUNCTION AFTER ON AND OFF PUMP CORONARY ARTERY BYPASS GRAFTING2014
  5. 5Renal implications of off-pump coronary artery bypass grafting: A retrospective cohort study analyzing postoperative creatinine levels2023