What does this research mean for the field?

Spatially localized Na-K pump inhibition causing sodium overloading can induce spontaneous, propagating ectopic beats in cardiac atrial networks, requiring a critical mass of approximately 1000 affected cells to propagate at realistic conduction velocities. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 22, 1993Proceedings of the Royal Society B Biological Sciences

Generation and propagation of ectopic beats induced by spatially localized Na–K pump inhibition in atrial network models

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Population

Biophysically detailed two-dimensional network model of the cardiac atrium (512 x 512 lattice of cells)

Design

Preclinical

Authors

RWRaimond L. WinslowElectrophysiology AVAnthony VargheseUniversity of Alabama at Birmingham DNDenis NobleElectrophysiology

Discussion

Member takes

Implication

May trigger atrial ectopy in models; hypothesis-generating and should not yet change practice.

Structured PICO

Population

Biophysically detailed two-dimensional network model of the cardiac atrium (512 x 512 lattice of cells)

Intervention

Spatially localized inhibition of the Na-K pump

Outcome

Generation and propagation of ectopic beatssurrogate

Computational modeling demonstrates that localized Na-K pump inhibition in a small cluster of cells can trigger propagating ectopic beats in atrial tissue.

Cite This Study

Winslow et al. (1993) studied this question.

synapsesocial.com/papers/6a155f1079ff98d0de4e8653 https://doi.org/10.1098/rspb.1993.0126

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Generation and propagation of ectopic beats induced by spatially localized Na–K pump inhibition in atrial network models

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Generation and propagation of ectopic beats induced by spatially localized Na–K pump inhibition in atrial network models

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider