Key result
Simulation of nonconducting media mimicking cardiac fibrosis in two models of cardiac tissue demonstrated the generation of reentry inside fibrotic tissues, resulting in ectopic pacemakers.
Why the study?
Does the inclusion of nonconducting media mimicking cardiac fibrosis in computational models generate ectopic beats?
Does the inclusion of nonconducting media mimicking cardiac fibrosis in computational models generate ectopic beats?
Computational modeling demonstrates that reentry restricted to microfibrosis regions can generate ectopic pacemakers, potentially triggering fibrillation.
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Findings warrant no practice change; hypothesis-generating for fibrosis reentry as ectopic trigger, needing in vivo validation.
Barros et al. (2015) studied Cardiac fibrosis and ectopic beats. Subcellular microscopic model and equivalent discrete model was evaluated on Generation of ectopic beats and reentry. Simulation of nonconducting media mimicking cardiac fibrosis in two models of cardiac tissue demonstrated the generation of reentry inside fibrotic tissues, resulting in ectopic pacemakers.
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