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November 9, 2018Journal of Biological ChemistryOpen Access

Prostaglandin E2 down-regulates sirtuin 1 (SIRT1), leading to elevated levels of aromatase, providing insights into the obesity–breast cancer connection

Kotha Subbaramaiah Neil M. Iyengar Monica Morrow Olivier Elemento Xi Kathy Zhou Andrew J. Dannenberg

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Abstract

promoter and reduced SIRT1 levels. These findings suggest that reduced SIRT1-mediated deacetylation of HIF-1α contributes to the elevated levels of aromatase in breast tissues of obese women.

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Subbaramaiah et al. (2018) studied this question.

synapsesocial.com/papers/6a155faccb0379474a822dda https://doi.org/10.1074/jbc.ra118.005866

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