Key result
Obesity with metabolic syndrome exhibits 24 differentially expressed plasma proteins versus obesity alone.
Why the study?
The mechanisms contributing to metabolic heterogeneity among individuals with obesity, specifically those who are metabolically healthy versus those with metabolic syndrome, are not fully understood.
Does the plasma inflammatory and cardiometabolic protein signature differ in individuals with obesity and metabolic syndrome compared to those with obesity alone?
Case-Control (n=48)
No
Does the plasma inflammatory and cardiometabolic protein signature differ in individuals with obesity and metabolic syndrome compared to those with obesity alone?
p-value: p=<0.05
Individuals with obesity and metabolic syndrome exhibit a distinct inflammatory and cardiometabolic plasma protein signature compared to those with obesity alone, highlighting potential therapeutic targets.
May identify therapeutic targets in obesity with metabolic syndrome; hypothesis-generating, requiring prospective validation before clinical adoption.
There is variability in the metabolic health status among individuals presenting with obesity; some may be metabolically healthy, while others may have developed the metabolic syndrome, a cluster including insulin resistance, hypertension, dyslipidemia, and increased risk of cardiovascular disease and type 2 diabetes. The mechanisms contributing to this metabolic heterogeneity are not fully understood. To address this question, plasma samples from 48 individuals with BMI ≥ 35 kg/m 2 were examined (27 with and 21 without metabolic syndrome). Fasting plasma samples were subjected to Olink proteomics analysis for 184 cardiometabolic and inflammation-enriched proteins. Data analysis showed a clear differentiation between the two groups with distinct plasma protein expression profiles. Twenty-four proteins were differentially expressed (DEPs) between the two groups. Pathways related to immune cell migration, leukocyte chemotaxis, chemokine signaling, mucosal inflammatory response, tissue repair and remodeling were enriched in the group with metabolic syndrome. Functional analysis of DEPs revealed upregulation of 15 immunological pathways. The study identifies some of the pathways that are altered and reflect metabolic health in individuals with obesity. This provides valuable insights into some of the underlying mechanisms and can lead to identification of therapeutic targets to improve metabolic health in individuals with obesity.
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Mir et al. (2023) conducted a case-control in Obesity with and without metabolic syndrome (n=48). Obesity with metabolic syndrome (OBM) vs. Obesity only (OBO) was evaluated on Differentially expressed proteins (DEPs) (p=<0.05). Individuals with obesity and metabolic syndrome exhibited a distinct plasma protein expression profile compared to those with obesity only, with 24 differentially expressed proteins identified.
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