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The fluorescent phospholipid 1-acyl-2-12-[(7-nitro-2,1,3-benzoxadiazol-4-yl)aminododecanoyl]phosphatidylcholine (C12-NBD-PC) was used to study the kinetics of lipid transfer between phospholipid vesicles. A model based on lipid transfer resulting from the diffusion of soluble monomers was found to accurately predict the kinetics of this transfer process. From these studies, we conclude that (i) C12-NBD-PC transfer between vesicles results from the diffusion of soluble monomers and not from vesicle collision, (ii) the rate at which a lipid molecule enters or leaves a bilayer is dependent upon both its molecular structure and the characteristics of the donor and acceptor bilayers, and (iii) under the appropriate conditions, either the rate of lipid association or dissociation from the bilayer or a combination of both may determine the rate of transfer.
Nichols et al. (Tue,) studied this question.
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