Key result
Percutaneous coronary intervention significantly increased the sum of mean Strain Rate values from 10.12 to 11.30 (P=0.001) at one week, but did not significantly change Strain values (P=0.1).
Why the study?
Because strain and strain rate change early in myocardial ischemia, this study aimed to compare changes in systolic strain and strain rate in patients with significant LAD stenosis before and after PCI.
Does percutaneous coronary intervention improve echocardiographic Strain and Strain Rate indices in patients with significant LAD stenosis?
Observational (n=48)
Does percutaneous coronary intervention improve echocardiographic Strain and Strain Rate indices in patients with significant LAD stenosis?
Absolute Event Rate: 11.3% vs 10.12%
p-value: p=0.001
PCI on the LAD significantly improves systolic Strain Rate indices within one week, suggesting its utility as an early marker of favorable response to revascularization.
Strain rate may mark early PCI response in LAD stenosis; hypothesis-generating pending larger prospective studies.
Introduction: Strain (S) and Strain Rate (SR) as echocardiography parameters are important in assessing changes in myocardial tissue and global and regional evaluation of systolic and diastolic functions and in detection of myocardial disorders as they change in early stages of myocardial ischemia. Therefore, the aim of this study was to compare changes of S and SR indices in systolic phase in patients with a significant stenosis of left anterior descending (LAD) before and after percutaneous coronary intervention (PCI).Methods: 48 patients candidate for PCI with significant lesion in LAD were enrolled in this study. Echocardiographic images taken one day before and a week after PCI. Echocardiographic scope of the LAD was defined as mid, basal, anteroseptal and mid-septal and apical segments then, S and SR parameters in all segments measured separately during systolic phase before and after PCI and compared together.Results: there was a significant increase after PCI only in two segments and SR values showed significant increase after PCI in four segments. In the analysis of sum of mean parameters, a significant increase was observed in SR values (10.12 to 11.30; P = 0.001), but not in S values (149.54 to 143.36; P = 0.1)Conclusions: The remedial effect of PCI on deformation values was observed in the first week. In early reperfusion period, S/SR indices have potential to be used as determinants of favorable response to revascularization therapy.
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Sarvestani et al. (2019) conducted an observational in Coronary Artery Disease with significant LAD stenosis (n=48). Percutaneous coronary intervention (PCI) vs. Baseline (before PCI) was evaluated on Sum of mean Strain Rate (SR) values in systolic phase (p=0.001). Percutaneous coronary intervention significantly increased the sum of mean Strain Rate values from 10.12 to 11.30 (P=0.001) at one week, but did not significantly change Strain values (P=0.1).
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