Key result
Aldosterone promotes cardiac death in heart failure likely through a combination of endothelial dysfunction, myocardial fibrosis, and autonomic imbalance.
The adverse effects of aldosterone in heart failure may fundamentally stem from its impact on endothelial nitric oxide, a mechanism termed 'aldosterone vasculopathy'.
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May support mineralocorticoid receptor antagonists in heart failure; leaves open dominant pathways for targeted trials.
Allan D. Struthers (2002) conducted a review in Heart failure. Aldosterone was evaluated. Aldosterone promotes cardiac death in heart failure likely through a combination of endothelial dysfunction, myocardial fibrosis, and autonomic imbalance.
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