Why the study?
What is the diagnostic performance of rheumatoid factor testing by latex fixation in rheumatic disease outpatients?
Population
8,287 outpatients with rheumatic disease
Design
Cross-sectional
Authors
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Supports high specificity of latex RF testing in outpatients; challenges prior assumptions of lower specificity and age-related titer increases.
What is the diagnostic performance of rheumatoid factor testing by latex fixation in rheumatic disease outpatients?
Latex testing for rheumatoid factor is highly specific for rheumatoid arthritis and its titer does not spuriously increase with age.
Wolfe et al. (1991) studied this question.
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