Key result
Mutations E125N and T141A in the Kir2.1 channel differentially affected Ba2+ blocking kinetics, with E125N decreasing both entry and exit rates and T141A affecting only the entry rate.
The residues E125 and T141 in the Kir2.1 channel play distinct roles in mediating Ba2+ block, affecting entry and binding kinetics.
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Does not alter clinical practice; extends mechanistic understanding of Kir2.1 Ba2+ block in preclinical models.
Alagem et al. (2001) studied Inwardly rectifying K+ channel function. Mutations E125N and T141A in Kir2.1 vs. Wild-type Kir2.1 channel was evaluated on Ba(2+) blocking kinetics (entry and exit rates). Mutations E125N and T141A in the Kir2.1 channel differentially affected Ba2+ blocking kinetics, with E125N decreasing both entry and exit rates and T141A affecting only the entry rate.
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