Population
Murine inward rectifier K+ channel Kir2.1 (wild-type and mutant forms)
Comparison
Rb+ and Cs+ as blocking ions, and site-directed… vs Wild-type channels
Design
Preclinical
Authors
Loading...
No immediate clinical implications; extends Kir2.1 selectivity mechanisms but leaves open translation to human electrophysiology.
The Asp172 residue in the M2 domain of the Kir2.1 channel plays a critical role in determining ionic selectivity and block by balancing charge and pore size.
Abrams et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: