Contributions of a negatively charged residue in the hydrophobic domain of the IRK1 inwardly rectifying K+ channel to K(+)-selective permeation
Population
IRK1 inwardly rectifying K+ channel
Comparison
Mutation of the aspartate residue in the second… vs Wild-type IRK1 channel (implied)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
No immediate clinical implications from this animal model; extends Kir channel selectivity models and leaves open human translation.
Structured PICO
P
Population
IRK1 inwardly rectifying K+ channel
I
Intervention
Mutation of the aspartate residue in the second putative transmembrane segment
C
Comparator
Wild-type IRK1 channel (implied)
O
Outcome
Channel's ability to distinguish between K+ and Rb+ ionssurrogate
The aspartate residue in the second transmembrane segment of the IRK1 channel contributes to a selectivity filter near the cytoplasmic end of the pore.
Cite This Study
Reuveny et al. (1996) studied this question.