Population
Murine inward rectifier potassium channel IRK1
Comparison
Site-directed mutagenesis of Asp172 to Glu, Gln… vs Wild-type IRK1 (implied)
Design
Preclinical
Authors
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Identifies Asp172 as key for IRK1 block; leaves open translation to human channelopathies or therapy.
The Asp172 residue in the IRK1 channel is essential for intrinsic gating and forms part of the binding site for internal Mg2+ blockage.
Stanfield et al. (1994) studied this question.