Population
Xenopus oocytes expressing inward-rectifier K(+) channels ROMK2 (Kir1.1b), IRK1 (Kir2.1), and their chimeras
Comparison
Heterologous expression of channel chimeras and… vs Wild-type ROMK2 and IRK1 channels
Design
Preclinical
Authors
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No immediate clinical implications from this animal study; leaves open domain contributions to human channel function.
The P-region and COOH terminus of inward-rectifier potassium channels contribute independently to their conductance and ion selectivity properties.
Choe et al. (2000) studied this question.
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