Key result
Early-life weight gain of 5-9.9 kg is linked to ~46% higher stroke risk in men.
Why the study?
The importance of weight change for the risk of stroke was not well known.
Does weight change during early- and mid-life affect the long-term risk of stroke and death in healthy men?
Cohort (n=2,014)
Does weight change during early- and mid-life affect the long-term risk of stroke and death in healthy men?
Effect estimate: HR 1.46 (95% CI 1.09-1.95)
Weight increase during early-life (since age 25), but not mid-life, is associated with an increased long-term risk of stroke in healthy men.
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Supports hypothesis-generating role of early-life weight trajectories in stroke; leaves open causal effects and need for prospective trials.
Prestgaard et al. (2020) conducted a cohort in Healthy men (n=2,014). Early-life weight change vs. Weight gain 0 to 4.9 kg was evaluated on Stroke (HR 1.46, 95% CI 1.09-1.95). Early-life weight gain of 5 to 9.9 kg, compared with 0 to 4.9 kg, was associated with an increased long-term risk of stroke in healthy men (HR 1.46; 95% CI 1.09-1.95).
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