Key result
Sustained obesity (average BMI ≥35 kg/m²) was associated with increased heart failure risk (HR 2.95; 95% CI 1.53-5.71) compared to normal BMI, even after adjusting for recent BMI.
Why the study?
Does sustained overweight/obesity and weight change increase the risk of acute myocardial infarction and heart failure in community-dwelling individuals?
Cohort (n=26,097)
Does sustained overweight/obesity and weight change increase the risk of acute myocardial infarction and heart failure in community-dwelling individuals?
Effect estimate: HR 2.95 (95% CI 1.53-5.71)
Sustained overweight or obesity over time is strongly associated with an increased risk of heart failure, even after adjusting for recent BMI, whereas recent BMI is more important for AMI risk.
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Sustained obesity may warrant long-term BMI tracking for HF risk; extends observational data on weight trajectories while leaving causality open.
Janszky et al. (2016) conducted a cohort in Acute myocardial infarction and heart failure (n=26,097). Average body mass index (BMI) and weight change vs. BMI between 18.5 and 22.4 kg/m2 and stable weight was evaluated on Acute myocardial infarction (AMI) and heart failure (HF) (HR 2.95, 95% CI 1.53-5.71). Sustained obesity (average BMI ≥35 kg/m²) was associated with increased heart failure risk (HR 2.95; 95% CI 1.53-5.71) compared to normal BMI, even after adjusting for recent BMI.
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