Daily injection of human leukocyte interferon for 1 week lowered plasma cholesterol levels and decreased the activity of postheparin plasma hepatic and lipoprotein lipases by 20% to 50%.
Observational (n=6)
Does daily injection of human leukocyte interferon alter plasma lipoproteins and lipase activity in healthy men?
Interferon administration lowers plasma lipoproteins and decreases lipase activity, highlighting a potential mechanism for lipid changes seen in acute and chronic infections.
The effect of interferon administration on the concentration of plasma lipoproteins and on the activity of postheparin plasma lipoprotein lipase and hepatic lipase was studied in six healthy men. Daily injection of human leukocyte interferon for 1 week lowered the plasma level of total cholesterol, very low density lipoprotein + low density lipoprotein cholesterol, high density lipoprotein cholesterol, and apolipoprotein A-1 in all subjects. Simultaneously, the activity of postheparin plasma hepatic lipase and lipoprotein lipase decreased by 20% to 50%. These observations may be of importance in the interpretation of lipoprotein changes seen in acute and chronic infections and should be borne in mind when prolonged treatment with interferon is considered.
Ehnholm et al. (Fri,) conducted a observational in Healthy (n=6). Human leukocyte interferon was evaluated on Concentration of plasma lipoproteins and activity of postheparin plasma lipases. Daily injection of human leukocyte interferon for 1 week lowered plasma cholesterol levels and decreased the activity of postheparin plasma hepatic and lipoprotein lipases by 20% to 50%.
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