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February 1, 1994Journal of Lipid ResearchOpen Access

Continuous intravenous heparin administration in humans causes a decrease in serum lipolytic activity and accumulation of chylomicrons in circulation.

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Why the study?

Does continuous intravenous heparin administration alter postprandial lipoprotein metabolism in patients with thromboembolic disease?

Population

17 patients with thromboembolic disease (11 treated with heparin, 6 controls)

Comparison

Continuous intravenous heparin drip of 1000 U/h… vs No heparin

Design

Cohort

Follow-up

4 days

Authors

MWMoshe WeintraubTRT. RassinSES Eisenberg

Discussion

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Overview

Continuous IV heparin was associated with chylomicron accumulation via reduced LPL; hypothesis-generating for lipid effects in thromboembolic disease and should not yet change practice.

Structured PICO

Does continuous intravenous heparin administration alter postprandial lipoprotein metabolism in patients with thromboembolic disease?

P
Population
17 patients with thromboembolic disease (11 treated with heparin, 6 controls)
I
Intervention
Continuous intravenous heparin drip of 1000 U/h for 4 days, maintaining PTT levels at twice the baseline
C
Comparator
No heparin (control group of 6 patients with thromboembolic disease in whom heparin therapy was not indicated)
O
Outcome
Postprandial lipoprotein metabolism measured by area below the chylomicron retinyl palmitate curve and postheparin lipoprotein lipase activitysurrogate

Continuous intravenous heparin administration for 4 days causes an accumulation of chylomicrons in the circulation, likely due to a marked decrease in serum lipolytic activity.

Cite This Study

Weintraub et al. (1994) studied this question.

synapsesocial.com/papers/6a8bf84d0ca85c7e33df1bbdhttps://doi.org/10.1016/s0022-2275(20)41211-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Effects of treatment with cholestyramine and gemfibrozil.1987 · 263 citations
  2. 2Enrichment of apolipoprotein B-48 in the LDL density class following in vivo inhibition of hepatic lipase1986 · 72 citations
  3. 3Kinetics of chylomicron remnant clearance in normal and in hyperlipoproteinemic subjects.1987 · 125 citations
  4. 4Lipoprotein Metabolism during Acute Inhibition of Hepatic Triglyceride Lipase in the Cynomolgus Monkey1982 · 262 citations
  5. 5Rate of elimination of the Intralipid fat emulsion from the circulation in ICU patients1982 · 50 citations