Why the study?
Does post-heparin plasma cause lipolysis of lipoproteins compared to pre-heparin serum in normal human subjects?
Population
Normal human subjects
Comparison
Post-heparin plasma incubated with egg… vs Pre-heparin serum from the same individuals…
Design
Preclinical
Follow-up
4 to 8 hours (incubation period)
Authors
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Supports heparin lipemia clearance mechanism in animals; leaves open human translation and clinical relevance.
Does post-heparin plasma cause lipolysis of lipoproteins compared to pre-heparin serum in normal human subjects?
This early study demonstrates that post-heparin plasma possesses lipolytic activity, providing a biochemical basis for the clearing of lipemic blood and lipoprotein redistribution observed after heparin administration.
Shore et al. (1953) studied this question.
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