Pulsed-wave Doppler and single-catheter pressure measurements yielded zero-frequency impedance values that strongly correlated with standard pulmonary vascular resistance (r=0.993).
Observational (n=12)
Does a novel method combining pulsed-wave Doppler flow and single-pressure measurements accurately estimate pulmonary vascular resistance and right ventricular work in children with pulmonary hypertension?
A novel method combining pulsed-wave Doppler and single-catheter pressure measurements accurately estimates pulmonary vascular resistance and right ventricular work, providing a comprehensive characterization of pulmonary hypertension in children.
BACKGROUND: Current evaluation of pulmonary hypertension (PH) in children involves measurement of pulmonary vascular resistance (PVR); however, PVR neglects important pulsatile components. Pulmonary artery (PA) input impedance and ventricular power (VP) include mean and pulsatile effects and have shown promise as alternative measures of vascular function. Here we report the utility of pulsed-wave (PW) Doppler-measured instantaneous flow and pressure measurements for estimation of input impedance and VP and use this method to develop a novel parameter: reactivity in compliance. METHODS AND RESULTS: An in vitro model of the general pulmonary vasculature was used to obtain impedance and VP, measured by PW Doppler and a reference flow meter. The method was then tested in a preliminary clinical study in subjects with normal PA hemodynamics (n=4) and patients with PH undergoing reactivity evaluation (8 patients; 23 data points). In vitro results showed good agreement between the impedance spectra computed from both flow-measurement methods. Excellent correlation was seen in vitro between actual resistance and the zero-frequency (Z(o)) impedance value (r2=0.984). Excellent agreement was also found between Z(o) and PVR in the clinical measurements (y=1.075x+0.73; r=0.993). Furthermore, total VP and VP/cardiac output increased significantly with hypertension (128.73 to 365.91 mW and 2.42 to 6.69 mW x mL(-1) x s(-1), respectively). The first-harmonic value of impedance (Z1) was used as a measure of compliance reactivity; older patients exhibited markedly less compliance reactivity than did younger patients. CONCLUSIONS: Input impedance and VP calculated from Doppler measurements and a single-catheter pressure measurement provide comprehensive characterization of PH and reactivity.
Weinberg et al. (Tue,) conducted a observational in Pulmonary Hypertension (n=12). Pulsed-wave Doppler and single-catheter pressure measurements vs. Standard pulmonary vascular resistance measurement was evaluated on Agreement between zero-frequency impedance (Z(o)) and pulmonary vascular resistance (PVR). Pulsed-wave Doppler and single-catheter pressure measurements yielded zero-frequency impedance values that strongly correlated with standard pulmonary vascular resistance (r=0.993).