Echocardiography based estimation of pulmonary vascular resistance in patients with pulmonary hypertension: a simultaneous Doppler echocardiography and cardiac catheterization study
Why the study?
Does Doppler echocardiography accurately estimate pulmonary vascular resistance compared to right heart catheterization in patients with pulmonary hypertension?
Population
30 patients with pulmonary hypertension undergoing right heart catheterization. Subtypes included idiopathic…
Comparison
Doppler echocardiography-derived estimation of… vs Invasive measurement of pulmonary vascular…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Supports non-invasive PVR estimation in PH; leaves open prospective validation before replacing catheterization.
Structured PICO
Does Doppler echocardiography accurately estimate pulmonary vascular resistance compared to right heart catheterization in patients with pulmonary hypertension?
P
Population
30 patients with pulmonary hypertension undergoing right heart catheterization (mean age 62 ± 13 years, 21 females). Subtypes included idiopathic PAH (n=5), associated PAH (n=16), chronic thromboembolic PH (n=6), interstitial lung disease (n=2), and after closure of an atrial septal defect (n=1). Excluded: impaired left ventricular systolic function (EF < 50%) or elevated pulmonary capillary wedge pressure (PCWP >15 mmHg).
I
Intervention
Doppler echocardiography-derived estimation of pulmonary vascular resistance (PVR) using the formula: PAMP = PASP(echo) × 0.61 + 2 mmHg, and PVR = (PAMP(echo) - 10) / cardiac output.
C
Comparator
Invasive measurement of pulmonary vascular resistance via right heart catheterization (gold standard).
O
Outcome
Correlation and agreement between Doppler-derived PVR and invasive RHC-derived PVR.surrogate
A novel Doppler echocardiography formula provides a non-invasive estimation of pulmonary vascular resistance that strongly correlates with invasive right heart catheterization in patients with pulmonary hypertension.
Cite This Study
Lindqvist et al. (2011) studied this question.