Key result
Antihypertensives including ACE inhibitors and diuretics are linked to differences in health-related quality of life.
Why the study?
Hypertension and its pharmacotherapy impact health-related quality of life, but the specific effects of different hypertensive medications remained to be determined.
Does antihypertensive pharmacotherapy impact health-related quality of life in hypertensive patients?
Cross-Sectional (n=263)
No
Does antihypertensive pharmacotherapy impact health-related quality of life in hypertensive patients?
In a cross-sectional survey of hypertensive patients in Pakistan, treatment with ACE inhibitors and diuretics was significantly associated with changes in health-related quality of life.
May warrant HRQoL monitoring with ACE inhibitors or diuretics; leaves open causality and practice implications.
Chronic diseases and their treatment regimen plays a greater role in determining the patient related health outcomes of which one is Health Related Quality of Life. Hypertension itself along with its pharmacotherapy impacts HRQoL of hypertensive patients. The primary objective of the study was to determine the impact of f hypertensive medications on the health-related quality of life among hypertensive patients with the secondary objective to assess which medication significantly affects health related quality of life of hypertensive patients. A quantitative questionnaire based cross-sectional survey was undertaken in outpatient departments of Sandeman Provisional Hospital (SPH) Quetta using an EQ-5D-3L to determine the Health-Related Quality of Life. Convenience Sampling technique was used for data collection. Majority of respondents (8.7%) had no problem in first three domains while having some problem in pain and anxiety domains. Following them 7.6% of patients had some problems in all domains of the EQ5D tool. Moreover. the ACE Inhibitors and Diuretics impacts HRQoL of patients of current study. A total of 263 participated in the study of which (25%) of the respondents were of age group 48 -75 years old and were married 73.4% mostly. Majority (8.7%) had no problem in first three domains while having some problem in pain and anxiety domains. ACE Inhibitors and Diuretics significantly influence the health status of hypertensive patients acquiring pharmacotherapy. It was concluded that antihypertensive agents have a significant impact on HRQoL of hypertensive patients especially Angiotensin Converting Enzymes and Diuretics, which show significant impact on HRQoL of hypertensive patients. However, it is also suggested to assess the impact of antihypertensive therapies given in combination must also be studied in order to provide health professionals a better understanding of their prescribed regimen to improve patient related health outcomes.
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Siddique et al. (2021) conducted a cross-sectional in Hypertension (n=263). Antihypertensive agents (including ACE Inhibitors and Diuretics) was evaluated on Health-Related Quality of Life (EQ-5D score). Antihypertensive agents, particularly ACE inhibitors (p=0.008) and diuretics (p=0.005), significantly influenced the health-related quality of life of hypertensive patients.
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