Key result
Alcohol consumption of 1 to 6 drinks per week was associated with a modestly lower risk of ischemic stroke compared with long-term abstainers (RR 0.75; 95% CI 0.53-1.06; P quadratic trend=0.06).
Why the study?
Does alcohol consumption reduce incident ischemic stroke in older adults free of cardiovascular disease?
Population
4,410 older adults free of cardiovascular disease at baseline from 4 US communities
Comparison
Alcohol consumption vs Long-term abstainers
Design
Cohort
Follow-up
average 9.2 years
Authors
Loading...
Should not change alcohol recommendations in older adults without CVD; leaves open a possible modest association with lower ischemic stroke risk.
Cohort (n=4,410)
Yes
Does alcohol consumption reduce incident ischemic stroke in older adults free of cardiovascular disease?
Effect estimate: RR 0.75 (95% CI 0.53 to 1.06)
p-value: p=0.06
Alcohol use shows a U-shaped association with ischemic stroke risk in older adults, with modestly lower risk at 1-6 drinks per week, though apoE4-positive individuals may face increased risk even with moderate intake.
Mukamal et al. (2005) conducted a cohort in Ischemic stroke (n=4,410). Alcohol consumption vs. Long-term abstainers was evaluated on Incident ischemic stroke (RR 0.75, 95% CI 0.53 to 1.06, p=0.06). Alcohol consumption of 1 to 6 drinks per week was associated with a modestly lower risk of ischemic stroke compared with long-term abstainers (RR 0.75; 95% CI 0.53-1.06; P quadratic trend=0.06).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: