What does this research mean for the field?

Angiotensin regulates catecholamine biosynthesis in adrenal medullary cells through short-term activation of tyrosine hydroxylase and long-term induction of tyrosine hydroxylase and phenylethanolamine N-methyltransferase gene expression, mediated by calcium signaling pathways. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1990Journal of Biological ChemistryOpen Access

Short and long term regulation of catecholamine biosynthetic enzymes by angiotensin in cultured adrenal medullary cells. Molecular mechanisms and nature of second messenger systems.

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Structured PICO

Population

Cultured bovine adrenal medullary (AM) cells

Intervention

[Sar1]angiotensin II (s1-AII) (e.g., 2 nM) for short (15-30 min) or long (3-72 h) term incubation

Comparator

Control (untreated cells)

Outcome

Enzyme activities and gene expression (mRNA levels) of tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT)surrogate

Angiotensin II regulates catecholamine biosynthesis in bovine adrenal medullary cells through increased gene expression of TH and PNMT mediated by calcium signaling.

Authors

MSMichal K. StachowiakBuffalo State University HJH K JiangHarbin Medical University APAlan PoisnerUniversity of Kansas

Discussion

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Implication

Extends angiotensin II effects on adrenal catecholamine biosynthesis to gene expression; leaves open in vivo and human relevance.

Cite This Study

Stachowiak et al. (1990) studied this question.

synapsesocial.com/papers/6a156b3f814bf8ec9a4e9058 https://doi.org/10.1016/s0021-9258(19)39618-8

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Short and long term regulation of catecholamine biosynthetic enzymes by angiotensin in cultured adrenal medullary cells. Molecular mechanisms and nature of second messenger systems.

Structured PICO

Discussion

Implication

Cite This Study

Short and long term regulation of catecholamine biosynthetic enzymes by angiotensin in cultured adrenal medullary cells. Molecular mechanisms and nature of second messenger systems.

Structured PICO

Discussion

Implication

Cite This Study

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