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January 1, 1999Canadian Journal of Physiology and Pharmacology

Functional involvement of angiotensin AT2 receptor in adrenal catecholamine secretion in vivo

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Population

anesthetized dogs

Comparison

Local administration of angiotensin II in the… vs AngII alone or basal state

Design

Preclinical

Authors

DMDaniel MartineauUniversité de MontréalSLStéphane LamoucheUniversité de MontréalRBRichard BriandGeorgetown University

Discussion

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Overview

AT2 receptors mediate AngII-stimulated adrenal catecholamine output in canines; leaves open translation to human physiology or therapy.

Structured PICO

P
Population
anesthetized dogs
I
Intervention
Local administration of angiotensin II (AngII) in the presence of either PD 123319 or CGP 42112 (angiotensin AT2 receptor ligands)
C
Comparator
AngII alone or basal state
O
Outcome
Adrenal catecholamine output (plasma concentrations of epinephrine and norepinephrine in adrenal venous and aortic blood)surrogate

In a canine model, AT2 receptors play a functional role in mediating adrenal catecholamine secretion in response to AngII.

Cite This Study

Martineau et al. (1999) studied this question.

synapsesocial.com/papers/6a82b6f50de57fd8eeb28fcbhttps://doi.org/10.1139/cjpp-77-5-367
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  1. 1Distribution and functional significance of angiotensin-II AT1-AND AT2-Receptor subtypes in the rat adrenal gland1998 · 53 citations
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