June 15, 1999Canadian Journal of Physiology and Pharmacology

Functional involvement of angiotensin AT2receptor in adrenal catecholamine secretion in vivo

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Population

anesthetized dogs

Comparison

Local administration of angiotensin II to the… vs Basal state and AngII administration alone

Design

Preclinical

Authors

DMDaniel MartineauUniversité de Montréal SLStéphane LamoucheUniversité de Montréal RBRichard BriandGeorgetown University

Discussion

Member takes

Overview

AT2 receptors mediate adrenal catecholamine responses in vivo; leaves open translation to human cardiovascular disease or therapy.

Structured PICO

Population

anesthetized dogs

Intervention

Local administration of angiotensin II (AngII) (0.05 µg, 0.1 µM) to the left adrenal gland in the presence of AT2 receptor ligands PD 123319 (0.085 µg to 8.5 µg) or CGP 42112 (0.005 µg to 5 µg)

Comparator

Basal state and AngII administration alone

Outcome

Adrenal gland catecholamine (epinephrine and norepinephrine) outputsurrogate

AT2 receptors play a functional role in mediating catecholamine secretion by the adrenal medulla in response to AngII in vivo.

Cite This Study

Martineau et al. (1999) studied this question.

synapsesocial.com/papers/6a71abd45d37378ac1dec2dc https://doi.org/10.1139/y99-037

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June 15, 1999Canadian Journal of Physiology and Pharmacology

Functional involvement of angiotensin AT2receptor in adrenal catecholamine secretion in vivo

View Full Paper

Ask AI

Bookmark

Population

anesthetized dogs

Comparison

Local administration of angiotensin II to the… vs Basal state and AngII administration alone

Design

Preclinical

Authors

DMDaniel MartineauUniversité de Montréal SLStéphane LamoucheUniversité de Montréal RBRichard BriandGeorgetown University

Discussion

Member takes

Overview

AT2 receptors mediate adrenal catecholamine responses in vivo; leaves open translation to human cardiovascular disease or therapy.

Structured PICO

Population

anesthetized dogs

Intervention

Local administration of angiotensin II (AngII) (0.05 µg, 0.1 µM) to the left adrenal gland in the presence of AT2 receptor ligands PD 123319 (0.085 µg to 8.5 µg) or CGP 42112 (0.005 µg to 5 µg)

Comparator

Basal state and AngII administration alone

Outcome

Adrenal gland catecholamine (epinephrine and norepinephrine) outputsurrogate

AT2 receptors play a functional role in mediating catecholamine secretion by the adrenal medulla in response to AngII in vivo.

Cite This Study

Martineau et al. (1999) studied this question.

synapsesocial.com/papers/6a71abd45d37378ac1dec2dc https://doi.org/10.1139/y99-037

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