Key result
Congestive cardiac failure was associated with significant decreases in ESR, WBC, Neutrophil, and MCHC, and significant increases in lymphocyte, monocyte, basophil, RBC, haematocrit, MCV, and MCH (P<0.05).
Why the study?
Does congestive cardiac failure alter hematological markers in patients compared to healthy controls?
Case-Control (n=50)
No
Does congestive cardiac failure alter hematological markers in patients compared to healthy controls?
p-value: p=<0.05
Congestive cardiac failure is associated with significant alterations in hematological markers, including reduced ESR and increased red and white cell lines, which may require clinical monitoring.
May warrant hematological monitoring in heart failure; leaves open prognostic value and causality.
Congestive Cardiac Failure (CCF) is a great threat to humanity whenever it occurs. It occurs more often in the elderly and is more in women. It brings about drastic alterations in the entire systems including the haematological system of the human body. Haematological markers are great indicators for health and disease. The study was done to determine the impact of congestive cardiac failure on haematological markers of the patients. The study was done in a Secondary health institution in Enugu. A total of fifty (50) subjects were selected for the study, 25 subjects were congestive cardiac failure subjects aged 74 ± 2.5 years and 25 subjects were apparently healthy individuals aged matched as the control. About 2 ml of venous blood sample was drawn from each subjects into EDTA anticoagulated container and used for the haematological investigations by Mindray BC-5300. The results were presented in tables as mean and standard deviation and analysed using student t-test and level of significance set at P<0.05. The results showed significant decrease (P<0.05) in ESR, WBC, Neutrophil, MCHC, significant increase (P<0.05) in lymphocyte, monocyte, basophil, RBC, haematocrit, MCV, MCH and no significant difference (P>0.05) in eosinophils of the congestive cardiac failure subjects compared to the control. The study showed reduced ESR and haemoglobinaemia which may overstress the heart. This condition is dangerous as the red cell line is highly increased as well as the white cell line. This is disastrous if not well managed. The clinicians should monitor the haematological markers especially the haemoglobin and the erythrocyte sedimentation rate in the patients to avert the danger to the patients which will correct when the patient recover from the disease.
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Obeagu et al. (2017) conducted a case-control in Congestive Cardiac Failure (n=50). Congestive Cardiac Failure vs. Apparently healthy individuals was evaluated on Haematological markers (ESR, WBC, Neutrophil, MCHC, lymphocyte, monocyte, basophil, RBC, haematocrit, MCV, MCH, eosinophils) (p=<0.05). Congestive cardiac failure was associated with significant decreases in ESR, WBC, Neutrophil, and MCHC, and significant increases in lymphocyte, monocyte, basophil, RBC, haematocrit, MCV, and MCH (P<0.05).
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