Key result
Polymorphisms in AT1 receptors and other angiotensin-related genes have a significant impact on organ remodeling processes of the heart and the kidney.
Design
Review
Authors
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May inform remodeling risk stratification; leaves open clinical utility of genotyping pending prospective trials.
This review highlights the diverse biological functions of angiotensin receptors, particularly AT1, and their role in organ remodeling.
Matsusaka et al. (1997) conducted a review in Angiotensin receptor function. Polymorphisms in AT1 receptors and other angiotensin-related genes have a significant impact on organ remodeling processes of the heart and the kidney.
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