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April 1, 1996The Annual Review of Pharmacology and Toxicology

Angiotensin Receptors and Their Therapeutic Implications

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Authors

BLBernard LassègueCross-Cutting CardiologyRAR. Wayne AlexanderGeneral / Preventive / Lipids

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Overview

Leaves open novel AT1/AT2-targeted therapies for hypertension and HF; extends mechanistic understanding without altering current practice.

Key Points

  • To review the pharmacological and molecular characteristics of angiotensin II receptor subtypes and assess their therapeutic potential in cardiovascular medicine.
  • Pharmacological and molecular biological classification of angiotensin II receptor subtypes and isoforms.
  • Evaluation of receptor structure, biochemical profiles, regulatory factors, and their links to cardiovascular pathologies.
  • AT1 receptors (including AT1A and AT1B) mediate the majority of classical angiotensin II cardiovascular actions, while AT2 receptors primarily function in developmental pathways.
  • Receptor dysregulation directly contributes to hypertension, restenosis after angioplasty, cardiac hypertrophy, heart failure, myocardial infarction, and ventricular remodeling.
  • Structural mapping of angiotensin receptors identifies specific molecular targets to guide the design of selective cardiovascular drugs.

Cite This Study

Lassègue et al. (1996) studied this question.

synapsesocial.com/papers/6a8ac5f2c716e89f35debe3ehttps://doi.org/10.1146/annurev.pa.36.040196.001433

Topics

Cardiovascular prevention
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Also Consider

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  1. 1Identification of two subtypes in the rat type I angiotensin II receptor1992 · 401 citations
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  4. 4A Randomized, Placebo-Controlled, Double-Blind, Parallel Study of Various Doses of Losartan Potassium Compared With Enalapril Maleate in Patients With Essential Hypertension1995 · 227 citations
  5. 5Mutation of Asp74 of the rat angiotensin II receptor confers changes in antagonist affinities and abolishes G-protein coupling.1993 · 168 citations