Key result
Cancer diagnosis linked to ~25% higher ischemic stroke risk in AF patients.
Why the study?
Despite evidence linking cancer and thrombosis, cancer is not part of the CHA2DS2VASc score.
Does the incorporation of cancer into the CHA2DS2-VASc score improve the prediction of stroke in patients with atrial fibrillation?
Cohort (n=101,185)
Yes
Does the incorporation of cancer into the CHA2DS2-VASc score improve the prediction of stroke in patients with atrial fibrillation?
Effect estimate: IRR 1.25 (95% CI 1.18-1.31)
Absolute Event Rate: 2.962% vs 2.377%
p-value: p=<0.01
Incorporating cancer diagnosis into the CHA2DS2-VASc score improves stroke risk prediction in patients with atrial fibrillation.
No takes yet. Share an insight, caveat, or question.
Cancer-associated stroke risk in AF should not yet alter CHA2DS2-VASc use; leaves open whether incorporation improves net reclassification.
Bungo et al. (2022) conducted a cohort in Atrial fibrillation (n=101,185). Cancer diagnosis (lung, colon, breast, prostate) vs. No cancer diagnosis was evaluated on Ischemic stroke rate per 100 person-years (IRR 1.25, 95% CI 1.18-1.31, p=<0.01). Cancer diagnosis significantly increased the incidence of ischemic stroke in patients with atrial fibrillation by 25% (IRR 1.25) compared to patients without cancer.
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