What does this research mean for the field?

There is no correlation between ventricular catecholamine content and the incidence of ventricular fibrillation during hypothermia in dogs, suggesting that the protective effects of reserpine and antithyroid treatments are instead due to the depression of tissue metabolism. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1963Canadian Journal of Biochemistry and Physiology

On the Relationship of Catecholamines and Thyroid Activity to Ventricular Fibrillation During Hypothermia in Dogs

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Why the study?

Do alterations in catecholamine levels or thyroid activity affect the incidence of ventricular fibrillation during hypothermia in dogs?

Population

Dogs under pentobarbitone anesthesia subjected to coronary occlusion during hypothermia

Comparison

Pretreatment with iproniazid, phenoxybenzamine… vs Control (implied)

Design

Preclinical

Authors

DVDaya R. VarmaMcGill University RGRichard A. GillisGeorgetown University KMK. I. MelvilleWestmead Hospital

Discussion

Member takes

Implication

Caution against extrapolating canine results to human VF prevention; hypothesis-generating for non-catecholamine mechanisms in hypothermic arrhythmias.

Structured PICO

Do alterations in catecholamine levels or thyroid activity affect the incidence of ventricular fibrillation during hypothermia in dogs?

Population

Dogs under pentobarbitone anesthesia subjected to coronary occlusion during hypothermia

Intervention

Pretreatment with iproniazid, phenoxybenzamine, reserpine, reserpine plus liothyronine sodium, thyroidectomy, or methimazole

Comparator

Control (implied)

Outcome

Incidence of ventricular fibrillation and catecholamine content of the left ventricle

In a canine model of hypothermia and coronary occlusion, protection against ventricular fibrillation by reserpine or antithyroid interventions does not correlate with myocardial catecholamine depletion, pointing instead to depressed tissue metabolism.

Cite This Study

Varma et al. (1963) studied this question.

synapsesocial.com/papers/6a156fd69b87f33fc69f8e01 https://doi.org/10.1139/o63-045

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February 1, 1963Canadian Journal of Biochemistry and Physiology

On the Relationship of Catecholamines and Thyroid Activity to Ventricular Fibrillation During Hypothermia in Dogs

View Full Paper

Ask AI

Bookmark

Why the study?

Do alterations in catecholamine levels or thyroid activity affect the incidence of ventricular fibrillation during hypothermia in dogs?

Population

Dogs under pentobarbitone anesthesia subjected to coronary occlusion during hypothermia

Comparison

Pretreatment with iproniazid, phenoxybenzamine… vs Control (implied)

Design

Preclinical

Authors

DVDaya R. VarmaMcGill University RGRichard A. GillisGeorgetown University KMK. I. MelvilleWestmead Hospital

Discussion

Member takes

Implication

Caution against extrapolating canine results to human VF prevention; hypothesis-generating for non-catecholamine mechanisms in hypothermic arrhythmias.

Structured PICO

Do alterations in catecholamine levels or thyroid activity affect the incidence of ventricular fibrillation during hypothermia in dogs?

Population

Dogs under pentobarbitone anesthesia subjected to coronary occlusion during hypothermia

Intervention

Pretreatment with iproniazid, phenoxybenzamine, reserpine, reserpine plus liothyronine sodium, thyroidectomy, or methimazole

Comparator

Control (implied)

Outcome

Incidence of ventricular fibrillation and catecholamine content of the left ventricle

Cite This Study

Varma et al. (1963) studied this question.

synapsesocial.com/papers/6a156fd69b87f33fc69f8e01 https://doi.org/10.1139/o63-045

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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