What does this research mean for the field?

There is no correlation between ventricular catecholamine content and the incidence of ventricular fibrillation during hypothermia in dogs; instead, the protective effects of reserpine and antithyroid treatments are likely due to the depression of tissue metabolism. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1963Canadian Journal of Biochemistry and Physiology

On the Relationship of Catecholamines and Thyroid Activity to Ventricular Fibrillation During Hypothermia in Dogs

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Why the study?

Do alterations in catecholamine levels or thyroid activity prevent ventricular fibrillation during hypothermia in dogs?

Population

Dogs under pentobarbitone anesthesia subjected to coronary occlusion during hypothermia

Comparison

Pretreatment with iproniazid, phenoxybenzamine… vs Implied untreated/control dogs

Design

Preclinical

Authors

DVDaya R. VarmaMcGill University RGRichard A. GillisGeorgetown University KMK. I. MelvilleWestmead Hospital

Discussion

Member takes

Implication

Questions catecholamine role in hypothermic VF; leaves open metabolic mechanisms for translational research.

Structured PICO

Do alterations in catecholamine levels or thyroid activity prevent ventricular fibrillation during hypothermia in dogs?

Population

Dogs under pentobarbitone anesthesia subjected to coronary occlusion during hypothermia

Intervention

Pretreatment with iproniazid, phenoxybenzamine, reserpine, reserpine + liothyronine sodium, thyroidectomy, or methimazole

Comparator

Implied untreated/control dogs

Outcome

Incidence of ventricular fibrillationsurrogate

In a canine model, protection against hypothermic ventricular fibrillation by reserpine or antithyroid interventions does not correlate with cardiac catecholamine depletion, pointing instead to depressed tissue metabolism.

Cite This Study

Varma et al. (1963) studied this question.

synapsesocial.com/papers/6a156fd69b87f33fc69f8e03 https://doi.org/10.1139/y63-045

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January 1, 1963Canadian Journal of Biochemistry and Physiology

On the Relationship of Catecholamines and Thyroid Activity to Ventricular Fibrillation During Hypothermia in Dogs

View Full Paper

Ask AI

Bookmark

Why the study?

Do alterations in catecholamine levels or thyroid activity prevent ventricular fibrillation during hypothermia in dogs?

Population

Dogs under pentobarbitone anesthesia subjected to coronary occlusion during hypothermia

Comparison

Pretreatment with iproniazid, phenoxybenzamine… vs Implied untreated/control dogs

Design

Preclinical

Authors

DVDaya R. VarmaMcGill University RGRichard A. GillisGeorgetown University KMK. I. MelvilleWestmead Hospital

Discussion

Member takes

Implication

Questions catecholamine role in hypothermic VF; leaves open metabolic mechanisms for translational research.

Structured PICO

Do alterations in catecholamine levels or thyroid activity prevent ventricular fibrillation during hypothermia in dogs?

Population

Dogs under pentobarbitone anesthesia subjected to coronary occlusion during hypothermia

Intervention

Pretreatment with iproniazid, phenoxybenzamine, reserpine, reserpine + liothyronine sodium, thyroidectomy, or methimazole

Comparator

Implied untreated/control dogs

Outcome

Incidence of ventricular fibrillationsurrogate

Cite This Study

Varma et al. (1963) studied this question.

synapsesocial.com/papers/6a156fd69b87f33fc69f8e03 https://doi.org/10.1139/y63-045

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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