Key result
Obese women with polycystic ovary syndrome had significantly higher carotid intima-media thickness (0.51 vs 0.39 mm, P<0.001) and lower vertebral artery flow volumes compared to healthy controls.
Why the study?
Does obese polycystic ovary syndrome increase carotid intima-media thickness and alter vertebro-basilar blood flow compared to healthy controls?
Case-Control (n=64)
Does obese polycystic ovary syndrome increase carotid intima-media thickness and alter vertebro-basilar blood flow compared to healthy controls?
Absolute Event Rate: 0.51% vs 0.39%
p-value: p=<0.001
Obese PCOS may signal early vascular changes; hypothesis-generating and should not yet change practice or screening.
AIM: To investigate the risk of cardiovascular disease by measuring carotid intima-media thickness (CIMT) and to evaluate the diameters and blood flow volume of vertebral arteries using Doppler ultrasound and the possible contribution of hyperandrogenemia that exists in these patients. MATERIAL AND METHODS: We prospectively studied 64 Caucasian women aged 18-35 years (31 with polycystic ovary syndrome [PCOS] and 33 healthy controls). Patients were classified according to body mass index into obese (BMI > 27 kg/m(2) ). All subjects were examined with ultrasound to measure CIMT and blood flow volume and diameters of vertebral arteries. RESULTS: A significant difference between the two groups in CIMT (0.51 ± 0.08 vs 0.39 ± 0.02 mm, P < 0.001) and diameters of vertebral arteries (right, 3.03 ± 0.37 vs 3.44 ± 0.68 mm and left, 2.94 ± 0.34 vs 3.33 ± 0.63 mm, P < 0.05) were found, respectively. Right-left and total flow volumes of the vertebral arteries (VA) were significantly lower in the PCOS group than in the control group (P ≤ 0.001). Compared to the control group, diameters of right and left VA decreased (P < 0.05). CONCLUSION: The results of this study suggest that hyperandrogenemia in obese PCOS patients affects carotid and vertebro-basilar system arteries wall thickness. Pre-atherosclerotic vascular impairment with androgen excess should determine early examination of vertebro-basilar system with ultrasound. All patients with PCOS must be routinely examined using color Doppler ultrasound to measure CIMT carotid and vertebro-basilar arteries, and diameters and blood flow volume of vertebral arteries.
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Çoksüer et al. (2011) conducted a case-control in Obese polycystic ovary syndrome (PCOS) (n=64). Obese polycystic ovary syndrome vs. Healthy controls was evaluated on Carotid intima-media thickness (CIMT) (p=<0.001). Obese women with polycystic ovary syndrome had significantly higher carotid intima-media thickness (0.51 vs 0.39 mm, P<0.001) and lower vertebral artery flow volumes compared to healthy controls.
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