Key result
Newly diagnosed metabolic syndrome is linked to an ~87% higher aortic stiffness index versus controls.
Why the study?
It was not identified whether metabolic syndrome causes alterations in aortic elasticity in the early period before significant atherosclerosis occurs.
Does metabolic syndrome alter the elastic characteristics of the aorta in patients without overt cardiovascular disease?
Cross-Sectional (n=155)
Does metabolic syndrome alter the elastic characteristics of the aorta in patients without overt cardiovascular disease?
Metabolic syndrome is associated with increased aortic stiffness and reduced elasticity even before the development of overt coronary artery disease, diabetes, or hypertension.
Answers are grounded in this paper and cite their sources.
May signal early vascular changes in metabolic syndrome; leaves open causality and need for prospective confirmation before clinical adoption.
Metabolic syndrome (MS) is a known risk factor of cardiovascular disease. However, it is not identified whether MS made alterations in the elasticity of the aorta in the early period before significant atherosclerosis occurred. The purpose of the study was to evaluate aortic elastic properties of patients who were newly diagnosed with MS. The research was performed among 100 patients of newly diagnosed MS (49 males; mean age 46 9 years) with normal sinus rhythm, and 55 cases without MS (29 males; mean age 45 9 years), matched by age . All participants underwent comprehensive physical and cardiological examination, biochemical examination, anthropological measurement and echocardiography. Aortic diameter change was significantly lower in MS group compared to control group (0.014 0.04 vs 0.25 0.1, p <0.01), aortic stiffness was significantly higher in the MS group (10.65 4.52 vs 5.7 2.42, p<0.01) compared to the age-matched control group. Multiple regression analysis shows that there is an independent relationship with each of the age, body mass index, HDL cholesterol and systolic blood pressure. Aortic stiffness index was higher in newly diagnosed MS patients compared to the control group. The vascular system can be affected even without diabetes, hypertension, hyperlipidemia, and coronary artery disease, which is excluded by history and noninvasive evaluation.
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Çakmak et al. (2021) conducted a cross-sectional in Metabolic Syndrome (n=155). Metabolic syndrome vs. Age-matched controls without metabolic syndrome was evaluated on Aortic stiffness index (p=<0.001). Newly diagnosed metabolic syndrome was associated with a significantly higher aortic stiffness index compared to age-matched controls (10.65 vs 5.7, p<0.001).
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