Key result
Patients with metabolic syndrome and angiographically normal coronary arteries had significantly lower aortic distensibility compared to healthy controls (1.64 vs 2.58 cm2.dyn-1.10-3, p<0.001).
Why the study?
Does metabolic syndrome reduce aortic distensibility in patients with angiographically normal coronary arteries?
Cross-Sectional (n=50)
Does metabolic syndrome reduce aortic distensibility in patients with angiographically normal coronary arteries?
Absolute Event Rate: 1.64% vs 2.58%
p-value: p=<0.001
Metabolic syndrome is associated with increased aortic stiffness (reduced distensibility) even in the absence of angiographically visible coronary artery disease.
Aortic stiffness may refine risk assessment in metabolic syndrome with normal coronaries; leaves open prognostic value and intervention effects.
Objective: In this study we aimed to investigate the parameters of aortic stiffness that were measured angiographically and the factors that effect these parameters in patients diagnosed as having metabolic syndrome and whose coronary arteries were normal angiographically. Materials and Methods: Thirty patients with metabolic syndrome and twenty patients without metabolic syndrome were included. Hemodynamic measurements were made during cardiac catheterization while the patients were in supine position. The systolic and diastolic diameters of aorta and parameters associated with aortic stiffness aortic strain and distensibility were measured.Results: When compared with the control group the systolic and diastolic blood pressure, pulse pressure, waist circumference, triglyceride and fasting plasma glucose levels were higher and HDL cholesterol level was lower in the metabolic syndrome group. Aortic strain was higher in the metabolic syndrome group but the statistical relation was non-significant (p=0,181). Moreover the distensibility was lower in the metabolic syndrome group and the statistical relation was significant (p
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Emül et al. (2013) conducted a cross-sectional in Metabolic syndrome with angiographically normal coronary arteries (n=50). Metabolic syndrome vs. Healthy controls without metabolic syndrome was evaluated on Aortic distensibility (cm2.dyn-1.10-3) (p=<0.001). Patients with metabolic syndrome and angiographically normal coronary arteries had significantly lower aortic distensibility compared to healthy controls (1.64 vs 2.58 cm2.dyn-1.10-3, p<0.001).
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