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May 3, 2005HypertensionOpen Access

Metabolic Syndrome Is Associated With Aortic Stiffness in Untreated Essential Hypertension

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Why the study?

Is metabolic syndrome associated with increased aortic stiffness in untreated essential hypertension?

Population

169 newly diagnosed, never treated, nondiabetic patients with essential hypertension

Comparison

Presence of metabolic syndrome (n=45) vs Absence of metabolic syndrome (n=124)

Design

Cross-sectional

Authors

GSGiuseppe SchillaciUniversity of PisaMPMatteo PirroGeneral / Preventive / LipidsGVGaetano VaudoUniversity of Foggia

Discussion

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Implication

Metabolic syndrome was associated with higher aortic stiffness in untreated hypertension; hypothesis-generating and requires prospective confirmation.

Structured PICO

Is metabolic syndrome associated with increased aortic stiffness in untreated essential hypertension?

P
Population
169 newly diagnosed, never treated, nondiabetic patients with essential hypertension (men 55%, mean age 48+/-11 years)
I
Intervention
Presence of metabolic syndrome (n=45)
C
Comparator
Absence of metabolic syndrome (n=124)
O
Outcome
Aortic pulse wave velocity measured by applanation tonometrysurrogate

In untreated essential hypertension, the presence of metabolic syndrome and central adiposity are independently associated with increased aortic stiffness, a known cardiovascular risk factor.

Cite This Study

Schillaci et al. (2005) studied this question.

synapsesocial.com/papers/6a1017675725bbd5cc607d83https://doi.org/10.1161/01.hyp.0000165313.84007.7d

Topics

Hypertension management
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Also Consider

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  1. 1Aortic Stiffness Is Associated With Visceral Adiposity in Older Adults Enrolled in the Study of Health, Aging, and Body Composition2001 · 390 citations
  2. 2Clustered Features of the Metabolic Syndrome and the Risk for Increased Aortic Pulse Wave Velocity in Middle-aged Japanese Men2003 · 79 citations
  3. 3Augmentation of central arterial pressure in Type 2 diabetes2001 · 111 citations
  4. 4Vascular Compliance as a Measure of Biological Age1999 · 57 citations
  5. 5Predictors of Cardiovascular Morbidity in Treated Hypertension: Results from the Primary Preventive Trial in Goteborg, Sweden1985 · 143 citations